The Solve M.E. Ramsay Grant Program is designed to build a research workforce for ME/CFS and Long Covid and to allow researchers to generate data to support larger grant applications.
Currently in its seventh year, the Ramsay network now includes 33 researchers from around the world and has resulted in more than $8 million dollars of additional research funding.
Check back soon for more details on our next round of applications!
Meet some of our awardees below and click on the pictures to learn more about their research projects.
“Enhanced External Counterpulsation (EECP), Non-invasive Approach to Treat Long Covid Fatigue”Principal Investigator: Dana Yelin, MD…
“Micro-clots, Skeletal Muscle Pain and Post-Exertional Malaise in Patients with Long Covid: From Pathophysiology to…
“Immunosenescence, Premature Aging of the Immune System in ME/CFS and the Response to Fecal Microbe…
“Targeting Atg13 in an Animal Model for ME/CFS”Principal Investigator: Avik Roy, PhD Home Avik Roy,…
“Effect of Stellate Ganglion Block on ME/CFS Symptoms and Plasma Metabolites”Principal Investigator: Deborah Duricka, PhDCo-Investigator:…
“Enriching the You + ME Registry: Exploring Access-to-care and Other Real World Data”Principal Investigator: Kevin…
Use this form to send them a note with congrats and your hopes for their scientific studies that will unfold over the coming years.
The Solve M.E. Ramsay Grant Program is designed to build a research workforce for ME/CFS and to allow researchers to generate data to support larger grant applications.
Currently in its sixth year, the Ramsay network now includes more than 80 researchers around the world and has resulted in more than $7 million dollars of additional research funding for ME/CFS.
Meet the teams below and click on the pictures to learn more about their research projects.
“ME/CFS and Long Covid: Are they the same condition?” Principal Investigator: Jennifer Stone (PhD) Australian National…
“Symptoms, mechanisms and sex: Exploring the sex differences in ME/CFSthrough integrated computational analyses”Principal Investigator: Sara Ballouz…
“Application of machine learning and text analytics in a cohort of people with ME/CFS and…
“Physiological and cognitive function in patients with PASC or ME before and afterinspiratory muscle training”Principal…
“Microbial aryl hydrocarbon receptor agonists in ME/CFS”Principal Investigator: David Esteban (PhD)Vassar College Home DAVID ESTEBAN “Microbial…
“Blood-brain barrier imaging as a biomarker for ME/CFS”Principal Investigator: Alon Friedman (MD, PhD)Dalhousie University and Emagix,…
“Discovery of pathological autoantibodies in ME/CFS and post-acute sequelae ofSARS-CoV-2 infection”Principal Investigator: Aaron Ring (MD, PhD)Yale…
2019 was our biggest year yet! We had over 30 researchers working across seven projects. The group represented 12 academic centers and organizations. Three of the studies were done collaboratively, integrating scientists from different labs.
Meet the teams below and learn more about their research projects.
“Altered T cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)”Principal Investigators: Liisa Selin (PhD), Anna Gil…
“Possible class II MHC deficiency in patients with Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS)”Principal…
“Defining the Postural Contributors to Post-Exertional Malaise (PEM) in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)”Principal Investigator:…
“Extensive characterization of the ME/CFS blood and cerebrospinal fluid microbiome + virome” Principal Investigators: Nikos…
“Unraveling Endothelial Function in ME/CFS” Principal Investigator: Francisco Westermeier (PhD)FH JOANNEUM University of Applied Sciences,…
“PARsing Post-Exertional Malaise: Does Post-Exertional Autonomic Recovery (PAR) Impact Post-Exertional Malaise? ”PrincipaI Investigator: Kegan Moneghetti,…
“Brain perfusion changes in chronic fatigue syndrome before and after exercise challenge”Principal Investigators: Michael Van…
The 2018 Request for Applications (RFA) received an enthusiastic response; double the number of applications were submitted compared to the 2017 cycle. From a collection of high quality proposals, seven projects received Ramsay funding at the beginning of 2019. Broadly, the investigators are researching mitochondrial dysfunction, immune-mediated inflammation, cell signaling, genetics, and infectious triggers.
The Ramsay 2018 PI’s include two expert researchers leading their first original studies in ME/CFS and two highly innovative early-career stage researchers. This group of researchers has a particular emphasis on unbiased bioinformatics approaches and the use of methods novel to the ME/CFS field, such as evaluating exosomes (vesicles released from cells that play a role in intercellular communication) and producing reprogrammed neurons to examine neuro-metabolic and molecular changes.
“Characterization of Janus kinase (JAK) activation profiles in ME/CFS subgroups”PI: Vincent Lombardi, PhDUniversity of Nevada,…
“Extracellular vesicles from ME/CFS Patients and their effect on human mast cells and microglia mediators…
“Whole genome sequencing and analysis of ME/CFS”PI: Elizabeth Worthey, PhDHudsonAlpha Institute Home LIZ WORTHEY AND…
“Biomarkers of mitochondrial dysfunction and signaling in ME/CFS”PI: Jonas Blomberg, MD, PhD, Anders Rosén, MD,…
“Endogenous retroviruses (ERVs) and their expression in chronic fatigue syndrome”PI: Dawei Li, PhDUniversity of Vermont…
“ME/CFS In a Petri Dish”PI: Assistant Professor Malav Trivedi, PhDNova Southeastern University Home MALAV TRIVEDI…
“Cross-sectional study to assess the prevalence of APOE e4 alleles in patients with ME/CFS and…
The second year of the Ramsays supported five projects investigating the involvement of autoimmunity, infectious triggers, immune cell metabolism, and the gut microbiome in ME/CFS. The 2017 cycle funded a graduate student-level PI to lead a study on the gut virome in a cohort of people with ME/CFS and household controls. It also brought in an expert computational biologist new to the field to study a hypotheses of gut microbiota-immune system interaction using a bioinformatics approach. The group has produced two scientific publications in Frontiers in Immunology from a study initiated by Prof. Jonas Blomberg (Uppsala University, Sweden). More manuscripts from this group are in process.
“Biomarkers for initiation (infection) and metabolic derangement in ME/CFS”PI: Jonas Blomberg, MD, PhD, Jonas Bergquist,…
“Epigenetics in Immune Cells”PI: Lubov Nathanson, PhDNova Southeastern University Home LUBOV NATHANSON “Epigenetics in Immune…
“Gut Microbiome & Autoantigens”PI: Eran Segal, PhDWeizmann Institute of Science Home ERAN SEGAL “Gut Microbiome…
“Investigating alterations in the intestinal virome in CFS/ME”PI: Fiona NewberryQuadram Institute and the University of…
“Metabolic Changes in T Cells & Monocytes”PI: Carmen Scheibenbogen, MDCharité—Universitätsmedizin Berlin in Germany Home CARMEN…
The inaugural group of Ramsay researchers explored hypotheses in diverse areas of science, including: neuroinflammation, autoimmunity, immune cell metabolism, virology, and mitochondrial functioning. To-date, researchers have produced three publications in Frontiers in Immunology, Genomic Medicine (a Nature publication), and Brain Imaging & Behavior. Dr. Geraldine (Jo) Cambridge and Fane Mensah received extension funding from SMCI for their Ramsay project to investigate altered energy utilization in the B cells of ME/CFS patients in an expanded pool of samples. Notably, pilot data from Dr. Jarred Younger’s Ramsay project showing evidence of neuroinflammation in individuals with ME/CFS was used to obtain a large, multi-year grant from the National Institutes of Health.
“Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance…
“Metabolic Analysis Of B-cell Maturation In ME/CFS”PI: Geraldine (Jo) Cambridge, PhDUniversity College London (UCL) Home…
“HHV-6 Mediated Mitochondrial Modulation and Its Association to ME/CFS”PI: Bhupesh Prusty, PhDUniversity of Wuerzberg Home…
“Autoimmune Signature in ME/CFS”PI: Carmen Scheibenbogen, MDCharité—Universitätsmedizin Berlin in Germany Home CARMEN SCHEIBENBOGEN “Autoimmune Signature…
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