What are ME/CFS & Long Covid?
Myalgic encephalomyelitis (ME), formerly known as chronic fatigue syndrome (CFS), is a chronic, complex, neuroimmune disease that profoundly limits the health and productivity of patients and is often triggered by an infection. Long Covid describes a collection of lingering symptoms following COVID-19.
They are thought to be related as they both can follow infection and exhibit many of the same prevalent symptoms: crippling fatigue, post-exertional malaise and cognitive dysfunction. There is no cure for either, nor are there any FDA-approved drugs or treatment so there is a dire need for more research into these disorders.
Core Programs
Solve M.E. takes a holistic approach to research and advocacy, catalyzing efforts through our various programs to make ME/CFS, Long Covid, and other “long haul” diseases better understood, diagnosable, and treatable. We are the largest U.S. peer-reviewed provider of private competitive research funding exclusively for ME/CFS, and the partner of choice for strategic, collaborative relationships with patients, researchers, government officials, and other disease organizations across the globe.
Groundbreaking Research
Our Research
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Forging Alliances
Join the LCADr. Akiko Iwasaki Wins Solve ME/CFS Catalyst Award
Dr. Akiko Iwasaki (Yale School of Medicine) wins the first Solve ME/CFS Catalyst Award for her study “Probing Functional Autoantibodies in Patients with ME/CFS.”
Solve ME/CFS Catalyst Awards
Solve’s ME/CFS Catalyst Awards provide targeted funding to promising research projects, helping them achieve impactful results faster.
Join Us For Advocacy Week 2025!
Educate Your Members of Congress About ME/CFS and Help #MoveMEForward.
Solve Science Spotlight
Read our easy-to-understand summaries of the latest and most impactful scientific studies.
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Donations from people like you allow Solve to invest in the most promising research and initiatives without delay.
About Us
The Solve ME/CFS Initiative (Solve M.E.) is a non-profit organization that serves as a catalyst for critical research into diagnostics, treatments, and cures for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Long Covid and other infection-associated chronic conditions and illnesses (IACCIs). Our work with the scientific, medical, and pharmaceutical communities, advocacy with government agencies, and alliances with patient groups around the world is laying the foundation for breakthroughs that can improve the lives of millions who suffer from various “long haul” diseases.
