Making Breakthroughs Possible

The most prevalent diseases you’ve never heard of


What are ME/CFS & Long Covid?

Myalgic encephalomyelitis (ME), formerly known as chronic fatigue syndrome (CFS), is a chronic, complex, neuroimmune disease that profoundly limits the health and productivity of patients and is often triggered by an infection. Long Covid describes a collection of lingering symptoms following COVID-19.

They are thought to be related as they both can follow infection and exhibit many of the same prevalent symptoms: crippling fatigue, post-exertional malaise and cognitive dysfunction. There is no cure for either, nor are there any FDA-approved drugs or treatment so there is a dire need for more research into these disorders.

Homepage Infographic with Long Covid & ME/CFS Statistics

Core Programs

Solve M.E. takes a holistic approach to research and advocacy, catalyzing efforts through our various programs to make ME/CFS, Long Covid, and other “long haul” diseases better understood, diagnosable, and treatable. We are the largest U.S. peer-reviewed provider of private competitive research funding exclusively for ME/CFS, and the partner of choice for strategic, collaborative relationships with patients, researchers, government officials, and other disease organizations across the globe.


Groundbreaking Research

Our Research

Harnessing the Power of Big Data

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Inspiring Advocacy

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Forging Alliances

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Solve is a Catalyst for Treatments and Cures

In this video, Solve leadership and advocates speak to the impact of our organization — how Solve centers the voices of patients, creates community, and provides hope.

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Take Action Now!

Ask your Members of Congress to support the CARE for Long COVID Act today.

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Long Covid's Prevalence and Economic Impact

Our Solve Long Covid Initiative launched a new whitepaper, Long Covid’s Impact on Adult Americans: Early Indicators Estimating Prevalence and Cost, estimating the magnitude of the Long Covid public health crisis.

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Long Covid: What Will It Take to Accelerate Therapeutic Progress?

Solve joined BIO to convene stakeholders that can help advance research and development for post-infection diseases. We engaged drug developers and informed them of the unmet needs of our communities to inspire them to study these diseases and create therapeutic breakthroughs.

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Long Haul Voices: Living with Long Covid and ME/CFS

Long Haul Voices is a mini-series created in partnership with Unfixed Media Productions that amplifies the experiences of individuals with Long Covid and ME/CFS, the experts devoted to improving their care, and the challenges surrounding these largely invisible, poorly-understood diseases that affect a rapidly growing population.


About Us

The Solve ME/CFS Initiative (Solve M.E.) is a non-profit organization that serves as a catalyst for critical research into diagnostics, treatments, and cures for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Long Covid and other post-infection diseases. Our work with the scientific, medical, and pharmaceutical communities, advocacy with government agencies, and alliances with patient groups around the world is laying the foundation for breakthroughs that can improve the lives of millions who suffer from various “long haul” diseases.