Making Breakthroughs Possible

The most prevalent diseases you’ve never heard of

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What are ME/CFS & Long Covid?

Myalgic encephalomyelitis (ME), formerly known as chronic fatigue syndrome (CFS), is a chronic, complex, neuroimmune disease that profoundly limits the health and productivity of patients and is often triggered by an infection. Long Covid describes a collection of lingering symptoms following COVID-19.

They are thought to be related as they both can follow infection and exhibit many of the same prevalent symptoms: crippling fatigue, post-exertional malaise and cognitive dysfunction. There is no cure for either, nor are there any FDA-approved drugs or treatment so there is a dire need for more research into these disorders.

Homepage Infographic with Long Covid & ME/CFS Statistics

Core Programs

Solve M.E. takes a holistic approach to research and advocacy, catalyzing efforts through our various programs to make ME/CFS, Long Covid, and other “long haul” diseases better understood, diagnosable, and treatable. We are the largest U.S. peer-reviewed provider of private competitive research funding exclusively for ME/CFS, and the partner of choice for strategic, collaborative relationships with patients, researchers, government officials, and other disease organizations across the globe.

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Groundbreaking Research

Our Research
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Harnessing the Power of Big Data

You + ME Registry
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Inspiring Advocacy

Make an Impact
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Forging Alliances

Join the LCA
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Solve Launches First National Long Covid PSA

“How Long?” was designed to broaden awareness of Long Covid, ME/CFS, and other post-infection diseases; create empathy for those who suffer its devastating impact; and highlight the need for research to better understand it in order to adequately help patients.

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Long Covid's Prevalence and Economic Impact

Our Solve Long Covid Initiative launched a new whitepaper, Long Covid’s Impact on Adult Americans: Early Indicators Estimating Prevalence and Cost, estimating the magnitude of the Long Covid public health crisis.

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Help Us Uncover Causes & Treatments

Designed for and by patients, the You + ME Registry community is made up of people with ME/CFS, people with Long Covid and control volunteers collectively providing the research community with critical insight into the lived experience and genetics of these and other post-infection diseases.

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Join Our Current Advocacy Efforts

Our online action tools make it easy to learn about the most current advocacy action items, connect with your elected officials, and share your story with your members of Congress.

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Long Haul Voices: Living with Long Covid and ME/CFS

Long Haul Voices is a mini-series created in partnership with Unfixed Media Productions that amplifies the experiences of individuals with Long Covid and ME/CFS, the experts devoted to improving their care, and the challenges surrounding these largely invisible, poorly-understood diseases that affect a rapidly growing population.

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About Us

The Solve ME/CFS Initiative (Solve M.E.) is a non-profit organization that serves as a catalyst for critical research into diagnostics, treatments, and cures for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Long Covid and other post-infection diseases. Our work with the scientific, medical, and pharmaceutical communities, advocacy with government agencies, and alliances with patient groups around the world is laying the foundation for breakthroughs that can improve the lives of millions who suffer from various “long haul” diseases.