Making Breakthroughs Possible

The most prevalent diseases you’ve never heard of

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What is ME / CFS?

Myalgic encephalomyelitis (ME), formerly known as chronic fatigue syndrome (CFS), is a chronic, complex, neuroimmune disease that profoundly limits the health and productivity of patients and is often triggered by an infection.

There is no cure for ME/CFS, nor are there any FDA-approved drugs or treatments. The main symptoms are extreme exhaustion (exacerbated by activity), cognitive dysfunction and unrefreshing sleep. Other symptoms may vary.

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Core Programs

Solve M.E. takes a holistic approach to research and advocacy, catalyzing efforts through our various programs to make ME/CFS, Long Covid, and other “long haul” diseases better understood, diagnosable, and treatable. We are the largest U.S. peer-reviewed provider of private competitive research funding exclusively for ME/CFS, and the partner of choice for strategic, collaborative relationships with patients, researchers, government officials, and other disease organizations across the globe.

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Groundbreaking Research

Our Research
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Harnessing the Power of Big Data

You + ME Registry
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Inspiring Advocacy

Make an Impact
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Forging Alliances

Join the LCA
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Dr. Anthony Fauci on ME/CFS & Long Covid

It’s extraordinary how many people have a post viral syndrome that’s very strikingly similar to myalgic encephalomyelitis/chronic fatigue syndrome. They just don’t get back to normal energy or normal feeling of good health.

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Share Your Story with Humans of M.E.!

It’s extraordinary how many people have a post viral syndrome that’s very strikingly similar to myalgic encephalomyelitis/chronic fatigue syndrome. They just don’t get back to normal energy or normal feeling of good health.

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Support Cures 2.0 Act

Take action to support this bill which addresses the Long Covid crisis, helps accelerate medical product development and brings new innovations and advances to patients who need them.

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About Us

The Solve ME/CFS Initiative (Solve M.E.) is a non-profit organization that serves as a catalyst for critical research into diagnostics, treatments, and cures for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Long Covid and other post-infection diseases. Our work with the scientific, medical, and pharmaceutical communities, advocacy with government agencies, and alliances with patient groups around the world is laying the foundation for breakthroughs that can improve the lives of millions who suffer from various “long haul” diseases.