Founded in 1987 and incorporated in North Carolina in 1990 as The Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS) Association of America, the Solve ME/CFS Initiative (Solve M.E.) relocated to Los Angeles, CA and officially changed our name in 2014. Solve M.E. is a non-profit disease organization that works to accelerate the discovery of safe and effective treatments, strives for an aggressive expansion of funding for research that will lead to a cure and seeks to engage the entire ME/CFS community in research, advocacy, and patient support. Solve M.E. is the foundational ME/CFS organization, steadily broadening strategic, collaborative relationships with patients, researchers, government officials and other ME organizations across the globe.

Our Vision:

A World Free of ME/CFS.

Our Mission:

Make ME/CFS widely understood, diagnosable, and treatable.

Our Core Values:

To lead with integrity, innovation and purpose.

Our Online Community:

Our Work

Filling Knowledge Gaps Through Original Research Solve M.E. designs and invests in innovative scientific studies to address severe knowledge gaps in ME/ CFS. Priority areas include the fields of bioenergetics, neuroendocrine biology, and inflammation and immunity. Our partners in these pursuits are leading experts in the field of ME/CFS. Solve M.E. has developed a portfolio of investments at some of the most prestigious medical centers and research laboratories in the United States and abroad.

Establishing a Patient Scientist Partnership Program for Diagnostic Testing and Clinical Applications This program facilitates patient participation in decision-making and defining research priorities.

Investing in Innovative Ideas Around the World: The Ramsay Awards This international program creates environments to attract, support and retain talent in the ME/CFS research community and helps awardees generate relevant data to compete for long-term federal funding, and facilitates collaboration and cross-pollination among researchers through the sharing of resources and access to additional programming and the organization’s network.

Facilitating Connection and Partnerships: SMCI’S MeetME Travel Awards The MeetME Travel Awards fund junior scientists and researchers from underrepresented groups to attend ME/ CFS conferences and help build scientific networks by paying their travel expenses for ME/CFS-focused meetings. A goal of this program is to attract new researchers to the field.

Creating Reliable Electronic Record Systems, Data Management Platforms, Biobanking and Patient Registries Our new, state-of-the-art national registry for ME/CFS will enable clinical trials, further understanding of the natural history of this disease, and includes built-in options for data sharing and collaboration among patients, researchers, and other disease organizations. This also includes a repository of physical samples from patients to support the work of qualified researchers and accelerate discovery.

Leading Conferences, Symposiums and Think Tanks Our think tanks attract the top minds in clinical care and research as well as leaders from federal health agencies, who collaborate on key issues facing ME/CFS. In addition to Solve M.E.-hosted events, Chief Scientific Officer Dr. Sadie Whittaker and members of our Research Advisory Council also participate and lead panels at the most prominent international medical conferences.

Advancing Medical Education Solve M.E. is the trusted source for up-to-date medical information, current research, and policy development. We debunk fallacies and restore the narrative through documentation, data and evidence-based presentations. We also lead public medical webinars and educational teleconference meetings that feature influencers in science, medicine, and policy, and publish scholarly articles in prestigious medical publications.

Partnering with Medical Agencies and Government Organizations Solve M.E. is a partner with key medical agencies and government organizations that include the National Institutes of Health (NIH) and the Centers for Disease Control (CDC) to influence the narrative, advocate for research funding, nurture promising findings, and articulate effective data-driven policies and solutions.

Driving Advocacy Solve M.E. acts as an agent for change and unity in the ME/ CFS community by focusing our efforts in advocating for policies, funding, and action. We meet with senior government officials, medical and industry leaders, and scientific pioneers; only a strong and multi-faceted coalition of stakeholders will effect change at the federal level. Solve M.E. authors dozens of opinion and technical pieces addressing current ME/CFS affairs across the science, research, and policy landscapes. Also, we debunk fallacies and misinformation.

Help us Solve ME/CFS

Solve ME/CFS Initiative relies on the generous support of patients, family members, and friends to sustain our important work. When you support us, you stand united with thousands of like-minded people who understand the devastation of this disease.

To make a secure online donation, go to

The Solve ME/CFS Initiative is a 501(c)(3) organization and donations are tax-deductible to the full extent allowed by law. We are fueled by gifts large and small, from people just like you.