New Study Explores Role of Energy-Regulating Enzyme PDH in ME/CFS

A new study entitled “Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome” by Fluge et al. was recently published in the leading Journal of Clinical Investigation. The study examined a total of 300 participants (approximately 200 ME/CFS patients, diagnosed according to the Canadian Consensus Criteria, alongside 100 healthy controls). Using blood […]

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January 2017 Research 1st – Dr. Nahle Letter

Dear Friends, With every new year, we renew our commitment to remain the uncompromising force working on behalf of patients. Indeed, our dedication to finding solutions to this disease has never been stronger or better focused. And while we scrape a dollar from here and a penny from there to survive as a non-profit research […]

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Dr. Maureen Hanson Visits SMCI to Discuss Ongoing Collaboration

On Thursday, January 5, Dr. Maureen Hanson of Cornell University visited SMCI’s Los Angeles headquarters. Dr. Hanson’s visit provided the opportunity to meet with SMCI President Carol Head and Chief Scientific Officer and Vice President for Research Dr. Zaher Nahle to discuss ongoing projects and collaborations on a number of studies. As you may know, […]

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SMCI-Directed Research Study Explores Immuno-senescence

Another of our SMCI-Directed Research Studies is being conducted in partnership with Dr. Sheila Stewart of Washington University in St. Louis in collaboration with Dr. Masashi Narita of the Narita Group at Cambridge University in England. This study explores immuno-senescence and cell-cycle analysis in the pathophysiology (or functional changes that accompany a particular syndrome or […]

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Ramsay Research Team 5 – The Potential Role of HHV-6 in ME/CFS

This study from Dr. Bhupesh Prusty (Julius Maximilian University of Wurzburg) is entitled “HHV-6 Mediated Mitochondrial Modulation and Its Association to ME/CFS.” While the precise role of pathogens in the development of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remains mostly uncharacterized, human herpesvirus 6 (HHV-6) is frequently associated with the disease (as well as several other […]

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Ramsay Research Team 4 – Identifying Autoimmune Signatures in ME/CFS

This study from Dr. Carmen Scheibenbogen (Charite University Medicine Berlin) and Madlen Lobel (Charite Universitatsmedizin Berlin) is entitled “Autoimmune Signature in CFS/ME.” It combines in-depth genetic screening methodologies with the study of autoimmune factors regulating a specific type of surface receptors important in cellular signaling and function. Three specific cellular and genetic autoimmune traits in […]

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Ramsay Research Team 3 – Metabolic Assessment of Natural Killer Cells in ME/CFS Using the Bioenergetics Health Index

This study, from Drs. Isabel Barao-Silvestre (University of Nevada Reno), Ruben Dagda (University of Nevada Reno), and Victor Darley-Usmar (University of Alabama at Birmingham), is entitled “The Bioenergetic Health Index of NK Cells as a Diagnostic Tool for Chronic Fatigue Syndrome.” Natural killer (NK) lymphocytes (a type of white blood cell) are a critical first […]

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Ramsay Research Team 2 – Studying B-Cell Function, Maturation, and Biochemical Alteration with Rituximab-Based Therapy

This study, from Dr. Geraldine Cambridge (University College London), Fane Mensah (University College London), and Chris Armstrong (University of Melbourne), is entitled “Metabolic Analysis of B-Cell Maturation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.” The study theorizes that while “many viral and other infectious agents have been reported to cause or trigger the symptoms described by patients […]

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Ramsay Research Team 1 – Exploring Brain Inflammation by Measuring Temperature

The study from Dr. Jarred Younger of the University of Alabama at Birmingham is entitled “Advanced Non-Invasive Analysis in ME/CFS Diagnosis and Treatment Decisions.” This study will use a magnetic resonance spectroscopic thermometry (MRSt) technique to assess absolute temperature across the entire brain. This technique allows researchers to investigate the pathophysiology (in other words, the […]

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The Ramsay Award Program Peer-Review Process

SMCI is the only ME/CFS organization to award seed grants for preliminary research, historically giving out seed grants once every three years. Our new, annual seed grant program, The Ramsay Award Program, will now give awards to promising researchers annually. When the Ramsay Award Program was established, we recognized that the development of a transparent, […]

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