In a new preprint, the DecodeME research team has shared its first analysis of DNA from people living with ME/CFS, marking a major milestone in the search for answers. The findings, based on over 15,000 genetic samples–the largest research study of the genetics of ME/CFS ever –shed new light on why some people are more likely to develop ME/CFS after a viral infection.
Solve has been an enthusiastic supporter of this endeavor from its early stages. DecodeME’s findings are a big win for the entire community.
Some DecodeME study highlights:
- People with ME/CFS have distinct genetic differences compared to the general population — spread across many parts of the genome rather than a single gene.
- Eight genetic “signals” have been identified, most tied to the immune and nervous systems.
- Because DNA is fixed, these signals point to underlying causes rather than effects of ME/CFS.
- Several of the signals are connected to how the body responds to infection.
- Others are linked to the nervous system, including one previously found in people with chronic pain — echoing the neurological symptoms described by many patients.
These early results will be examined and debated within the scientific community, and the conclusions may evolve as the research is finalized. Still, they represent a groundbreaking step toward understanding the biological roots of ME/CFS.
Read the preprint here and DecodeME’s announcement of the study findings here, and their study FAQ page here.