{"id":28621,"date":"2018-01-01T01:04:22","date_gmt":"2018-01-01T01:04:22","guid":{"rendered":"https:\/\/solvecfs.org\/?post_type=researcher&#038;p=28621"},"modified":"2021-12-09T02:12:50","modified_gmt":"2021-12-09T02:12:50","slug":"dawei-li","status":"publish","type":"researcher","link":"https:\/\/solvecfs.org\/research-and-registry\/ramsay-research-grants\/meet-the-researchers\/dawei-li\/","title":{"rendered":"Dawei Li, PhD"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"28621\" class=\"elementor elementor-28621\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6a819b1b elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-hidden-tablet_extra elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6a819b1b\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7e19f68d\" data-id=\"7e19f68d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5f32c25c elementor-widget elementor-widget-text-editor\" data-id=\"5f32c25c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u201cEndogenous retroviruses (ERVs) and their expression in chronic fatigue syndrome\u201d<br \/>PI: Dawei Li, PhD<br \/>University of Vermont<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-28fcaa99 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"28fcaa99\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-199c02f5\" data-id=\"199c02f5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-24e555f elementor-widget elementor-widget-ha-breadcrumbs happy-addon ha-breadcrumbs happy-addon-pro\" data-id=\"24e555f\" data-element_type=\"widget\" data-widget_type=\"ha-breadcrumbs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<ul class=\"ha-breadcrumbs\"><li class=\"ha-breadcrumbs-item ha-breadcrumbs-start\"><a href=\"https:\/\/solvecfs.org\/\" rel=\"home\"><span class=\"ha-breadcrumbs-text\">Home<\/span><\/a><\/li><\/ul>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3402f62c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3402f62c\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1e85b35d animated-fast\" data-id=\"1e85b35d\" data-element_type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e38c23a elementor-widget elementor-widget-heading\" data-id=\"e38c23a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">DAWEI LI<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d8fe197 elementor-widget elementor-widget-text-editor\" data-id=\"d8fe197\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u201cEndogenous retroviruses (ERVs) and their expression in chronic fatigue syndrome\u201d<br \/>PI: Dawei Li, PhD<br \/>University of Vermont<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-50f5eb16 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"50f5eb16\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-46498058\" data-id=\"46498058\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-50095e4b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"50095e4b\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-15df8906\" data-id=\"15df8906\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7460f44 elementor-widget elementor-widget-image\" data-id=\"7460f44\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/solvecfs.org\/wp-content\/uploads\/elementor\/thumbs\/Dawei-Li-pdxv1ok571j7vn2rv6mp3wxifgiq5pqub3onssr3bw.png\" title=\"Dawei-Li\" alt=\"Dawei-Li\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-6ec25809\" data-id=\"6ec25809\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1d3ab5dc elementor-widget elementor-widget-text-editor\" data-id=\"1d3ab5dc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Dr. Dawei Li will use a novel algorithm developed by the&nbsp;<u><a href=\"https:\/\/www.uvm.edu\/genomics\/index.html\">University of Vermont Li Laboratory<\/a><\/u>&nbsp;bioinformatics team to identify and type genome-wide endogenous retroviruses (ERVs). ERVs are viral elements in our genome that are derived from retroviruses. If successful, the study could identify genetic and viral causes of ME\/CFS in severely ill patient cohorts identified by Drs. Alain Moreau (Universit\u00e9 de Montr\u00e9al), Ron Davis (Stanford University) &amp; Wenzhong Xiao (Harvard University), and Alan Light (University of Utah). Dr. Li has set up a powerful collaboration that will leverage the collective knowledge and innovation across five laboratories.<\/p>\n<p><strong>Major Ramsay goals fulfilled:<\/strong><br><strong>\u2713 Bringing new researchers into the field.&nbsp;<\/strong>The Ramsay awards allowed Dr. Li, an innovative early career-stage researcher, to lead his first study on ME\/CFS<\/p><p><span style=\"letter-spacing: -0.2px;\">Read a paper describing ERVcaller, a novel methodology to comprehensively analyze genome-wide ERVs, developed by Dr. Li\u2019s lab&nbsp;<\/span><u style=\"letter-spacing: -0.2px;\"><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/332833v5\" style=\"font-family: var( --e-global-typography-6c6163f-font-family ), Sans-serif; font-size: var( --e-global-typography-6c6163f-font-size ); font-weight: var( --e-global-typography-6c6163f-font-weight ); font-style: var( --e-global-typography-6c6163f-font-style ); line-height: var( --e-global-typography-6c6163f-line-height ); letter-spacing: var( --e-global-typography-6c6163f-letter-spacing );\">here<\/a><\/u><br><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-411e89ac elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"411e89ac\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-49fcebe3 elementor-widget elementor-widget-heading\" data-id=\"49fcebe3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">\u201cIt is our hope that this project might lead to identification of endogenous retrovirus signatures that distinguish ME\/CFS from a healthy condition. The long-term goal of our research is to establish genetic markers and, ultimately, a treatment for ME\/CFS. Despite its prevalence and impact, ME\/CFS receives little research funding from the NIH. I hope that this project will help demystify a devastating and understudied disease. I am fortunate to have been introduced into this fascinating field.\u201d <\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e29afd7 elementor-widget elementor-widget-text-editor\" data-id=\"e29afd7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><em>-Dr. Li<\/em><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1444d56 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"1444d56\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2fa65790 elementor-widget elementor-widget-text-editor\" data-id=\"2fa65790\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>Read the research team\u2019s project summary below:<\/strong><u><\/u><\/p><p>Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a severe debilitating disease that affects approximately 1.3 million Americans. Currently, no molecular biomarkers or FDA-approved treatments are available. The causes of ME\/CFS remain unknown; however, ME\/CFS is known to be a chronic inflammatory disease. Endogenous retroviruses (ERVs), which comprise 8% of the human genome, are elements derived from ancient retroviruses. Most ERV elements normally remain silent; however, with certain biological triggers some ERVs can be activated to express viral proteins. Due to the viral nature, expression of ERVs may trigger response of the human immune system. We hypothesize that ERVs have significant impacts on the immune response and chronic inflammation features seen in ME\/CFS patients.<br \/>In this project, we will carry out a comprehensive analysis of genome-wide ERVs and their gene expression to identify ERV signatures that are associated with proinflammatory cytokines and ME\/CFS outcomes. If successful, findings from this project would prompt a new paradigm for thinking of ME\/CFS as a disorder of ERV super-activation and suggest that anti-retroviral or anti-inflammatory drugs could be therapeutic for individual ME\/CFS patients.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8a52ffe elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8a52ffe\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-12f04d96\" data-id=\"12f04d96\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-674d82cc elementor-widget elementor-widget-heading\" data-id=\"674d82cc\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Learn more about the Ramsay Grants<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3b4b01cb elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b4b01cb\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-4e63734b\" data-id=\"4e63734b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2985e78 elementor-widget elementor-widget-ha-member happy-addon ha-member\" data-id=\"2985e78\" data-element_type=\"widget\" data-widget_type=\"ha-member.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\n\t\t\t\t\t<figure class=\"ha-member-figure\">\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1104\" height=\"1072\" src=\"https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/M-Riederer_F-Westermeier_J-Blauensteiner-1-1.jpg\" class=\"elementor-animation-disable-animation attachment-full size-full wp-image-27383\" alt=\"M-Riederer-F-Westermeier-J-Blauensteiner\" srcset=\"https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/M-Riederer_F-Westermeier_J-Blauensteiner-1-1.jpg 1104w, https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/M-Riederer_F-Westermeier_J-Blauensteiner-1-1-300x291.jpg 300w, https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/M-Riederer_F-Westermeier_J-Blauensteiner-1-1-1024x994.jpg 1024w, https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/M-Riederer_F-Westermeier_J-Blauensteiner-1-1-768x746.jpg 768w\" sizes=\"(max-width: 1104px) 100vw, 1104px\" \/>\t\t\t<\/figure>\n\t\t\n\t\t<div class=\"ha-member-body\">\n\t\t\t<h4 class=\"ha-member-name\">Meet the Researchers<\/h4>\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t\t\t<a class=\"ha-btn ha-btn--link ha-btn--icon-after\" href=\"https:\/\/solvecfs.org\/research-and-registry\/ramsay-research-grants\/meet-the-researchers\/\"><span class=\"ha-btn-text\">Learn more<\/span> <i class=\"ha-btn-icon fas fa-chevron-right\" aria-hidden=\"true\"><\/i><\/a>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-4fbd4b39\" data-id=\"4fbd4b39\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-67e1f072 elementor-widget elementor-widget-ha-member happy-addon ha-member\" data-id=\"67e1f072\" data-element_type=\"widget\" data-widget_type=\"ha-member.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\n\t\t\t\t\t<figure class=\"ha-member-figure\">\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"777\" src=\"https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/apply-for-a-grant-1024x994.jpg\" class=\"elementor-animation-disable-animation attachment-large size-large wp-image-27384\" alt=\"apply-for-a-grant\" srcset=\"https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/apply-for-a-grant-1024x994.jpg 1024w, https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/apply-for-a-grant-300x291.jpg 300w, https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/apply-for-a-grant-768x746.jpg 768w, https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/apply-for-a-grant.jpg 1104w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t<\/figure>\n\t\t\n\t\t<div class=\"ha-member-body\">\n\t\t\t<h4 class=\"ha-member-name\">Apply for a Grant<\/h4>\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t\t\t<a class=\"ha-btn ha-btn--link ha-btn--icon-after\" href=\"https:\/\/solvecfs.org\/research-and-registry\/ramsay-research-grants\/apply-for-a-grant\/\"><span class=\"ha-btn-text\">Learn more<\/span> <i class=\"ha-btn-icon fas fa-chevron-right\" aria-hidden=\"true\"><\/i><\/a>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-2d65f7d2\" data-id=\"2d65f7d2\" 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