{"id":28551,"date":"2021-01-01T01:04:25","date_gmt":"2021-01-01T01:04:25","guid":{"rendered":"https:\/\/solvecfs.org\/?post_type=researcher&#038;p=28551"},"modified":"2022-02-17T18:29:40","modified_gmt":"2022-02-17T18:29:40","slug":"aaron-ring","status":"publish","type":"researcher","link":"https:\/\/solvecfs.org\/research-and-registry\/ramsay-research-grants\/meet-the-researchers\/aaron-ring\/","title":{"rendered":"Aaron Ring, MD, PhD"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"28551\" class=\"elementor elementor-28551\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-768cacd6 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-hidden-tablet_extra elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"768cacd6\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-173ffcba\" data-id=\"173ffcba\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1a1339c3 elementor-widget elementor-widget-text-editor\" data-id=\"1a1339c3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>\u201cDiscovery of pathological autoantibodies in ME\/CFS and post-acute sequelae of<br \/>SARS-CoV-2 infection\u201d<\/strong><br \/>Principal Investigator:\u00a0<a href=\"https:\/\/medicine.yale.edu\/profile\/aaron_ring\/\" target=\"_blank\" rel=\"noopener\">Aaron Ring (MD, PhD)<\/a><br \/>Yale University<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-51e5fa3d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"51e5fa3d\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-11bcd3b5\" data-id=\"11bcd3b5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-251a85fe elementor-widget elementor-widget-ha-breadcrumbs happy-addon ha-breadcrumbs happy-addon-pro\" data-id=\"251a85fe\" data-element_type=\"widget\" data-widget_type=\"ha-breadcrumbs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<ul class=\"ha-breadcrumbs\"><li class=\"ha-breadcrumbs-item ha-breadcrumbs-start\"><a href=\"https:\/\/solvecfs.org\/\" rel=\"home\"><span class=\"ha-breadcrumbs-text\">Home<\/span><\/a><\/li><\/ul>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-46a87f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"46a87f\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-27dc7166 animated-fast\" data-id=\"27dc7166\" data-element_type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-315b25dc elementor-widget elementor-widget-heading\" data-id=\"315b25dc\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">AARON RING<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4ef596c elementor-widget elementor-widget-text-editor\" data-id=\"4ef596c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>\u201cDiscovery of pathological autoantibodies in ME\/CFS and post-acute sequelae of<br \/>SARS-CoV-2 infection\u201d<\/strong><br \/>Principal Investigator:\u00a0<a href=\"https:\/\/medicine.yale.edu\/profile\/aaron_ring\/\" target=\"_blank\" rel=\"noopener\">Aaron Ring (MD, PhD)<\/a><br \/>Yale University<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-20ee636b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"20ee636b\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7dca6c97\" data-id=\"7dca6c97\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3101dde3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3101dde3\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-2d8bcdb6\" data-id=\"2d8bcdb6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1560ecaa elementor-widget elementor-widget-image\" data-id=\"1560ecaa\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/solvecfs.org\/wp-content\/uploads\/elementor\/thumbs\/aaron-ring-pdw7yrb8mtxowcjvlt5h2mww7rustq08jt3igmd2u4.png\" title=\"aaron-ring\" alt=\"aaron-ring\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3beaa1e7\" data-id=\"3beaa1e7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3bec7448 elementor-widget elementor-widget-text-editor\" data-id=\"3bec7448\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>Collaborators:<\/strong>\u00a0Jill Jaycox, PhD<br \/>Yale University<\/p><p>Aaron Ring, PhD, (Principal Investigator) is an associate professor of immunobiology at Yale University. His laboratory focuses on understanding and manipulating the activity of immune receptors using precision pharmacology and on applying methods in which desired traits are created through repeated rounds of genetic changes to create new pharmacological tools and therapeutics for the immune system.\u00a0<\/p><p>Dr. Ring will examine autoantibody reactivities of ME\/CFS patients using a technique called Rapid Extracellular Autoantibody Profiling (REAP). This study will build on previous work of autoantibodies in ME\/CFS by using a technology and approach that will give this disease mechanism a much more in-depth investigation. Dr. Ring will also compare the ME\/CFS data to a previously studied Long Covid cohort. A more rigorous investigation of a potential autoimmune component of ME\/CFS could open the door to biomarkers and a host of therapies (for example, B-cell depleting drugs).\u00a0<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-8b5a1c3 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"8b5a1c3\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a308c7d elementor-widget elementor-widget-text-editor\" data-id=\"a308c7d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><b>Study Summary&nbsp;<\/b><\/p><p>ME\/CFS is a debilitating, multisystemic condition of uncertain etiology. However, evidence of immune system dysfunction, including the presence of autoantibodies, is well-established in ME\/CFS patients. While some patients benefit from B cell \u2013 or antibody-depleting therapies, the role and significance of autoantibodies in ME\/CFS pathophysiology is not well understood.&nbsp;<\/p><p>In this grant, we propose to use Rapid Extracellular Antigen Profiling (REAP) to comprehensively assess the autoantibody reactivities of ME\/CFS patients against 4,200 extracellular human proteins and 50 pathogen antigens expressed in a yeast display library.&nbsp;<\/p><p>Then we will assess the biological functionality of these autoantibodies using ex vivo assays. With statistical modeling, we will ask whether specific ME\/CFS reactivities correlate with clinical parameters or symptoms and whether autoantibodies can be used as a framework to subset patients within this heterogeneous diagnosis.<\/p><p>Overall, this work represents the first comprehensive and unbiased survey of autoantibody reactivities in ME\/CFS. We believe our findings will generate novel insights into the role of humoral autoimmunity in ME\/CFS pathophysiology.&nbsp;<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1796c0f3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1796c0f3\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3aaa4654\" data-id=\"3aaa4654\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-295e7777 elementor-widget elementor-widget-heading\" data-id=\"295e7777\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Learn more about the Ramsay Grants<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-32c0195d elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"32c0195d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-65d15831\" data-id=\"65d15831\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3d2aa5e4 elementor-widget elementor-widget-ha-member happy-addon ha-member\" data-id=\"3d2aa5e4\" data-element_type=\"widget\" data-widget_type=\"ha-member.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\n\t\t\t\t\t<figure class=\"ha-member-figure\">\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1104\" height=\"1072\" src=\"https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/M-Riederer_F-Westermeier_J-Blauensteiner-1-1.jpg\" class=\"elementor-animation-disable-animation attachment-full size-full wp-image-27383\" alt=\"M-Riederer-F-Westermeier-J-Blauensteiner\" srcset=\"https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/M-Riederer_F-Westermeier_J-Blauensteiner-1-1.jpg 1104w, https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/M-Riederer_F-Westermeier_J-Blauensteiner-1-1-300x291.jpg 300w, https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/M-Riederer_F-Westermeier_J-Blauensteiner-1-1-1024x994.jpg 1024w, https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/M-Riederer_F-Westermeier_J-Blauensteiner-1-1-768x746.jpg 768w\" sizes=\"(max-width: 1104px) 100vw, 1104px\" \/>\t\t\t<\/figure>\n\t\t\n\t\t<div class=\"ha-member-body\">\n\t\t\t<h4 class=\"ha-member-name\">Meet the Researchers<\/h4>\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t\t\t<a class=\"ha-btn ha-btn--link ha-btn--icon-after\" href=\"https:\/\/solvecfs.org\/research-and-registry\/ramsay-research-grants\/meet-the-researchers\/\"><span class=\"ha-btn-text\">Learn more<\/span> <i class=\"ha-btn-icon fas fa-chevron-right\" aria-hidden=\"true\"><\/i><\/a>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-71f915a4\" data-id=\"71f915a4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6a613e4 elementor-widget elementor-widget-ha-member happy-addon ha-member\" data-id=\"6a613e4\" data-element_type=\"widget\" data-widget_type=\"ha-member.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\n\t\t\t\t\t<figure class=\"ha-member-figure\">\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"777\" src=\"https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/apply-for-a-grant-1024x994.jpg\" class=\"elementor-animation-disable-animation attachment-large size-large wp-image-27384\" alt=\"apply-for-a-grant\" srcset=\"https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/apply-for-a-grant-1024x994.jpg 1024w, https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/apply-for-a-grant-300x291.jpg 300w, https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/apply-for-a-grant-768x746.jpg 768w, https:\/\/solvecfs.org\/wp-content\/uploads\/2021\/09\/apply-for-a-grant.jpg 1104w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t<\/figure>\n\t\t\n\t\t<div class=\"ha-member-body\">\n\t\t\t<h4 class=\"ha-member-name\">Apply for a Grant<\/h4>\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t\t\t<a class=\"ha-btn ha-btn--link ha-btn--icon-after\" href=\"https:\/\/solvecfs.org\/research-and-registry\/ramsay-research-grants\/applying-for-a-grant\/\"><span class=\"ha-btn-text\">Learn more<\/span> <i class=\"ha-btn-icon fas fa-chevron-right\" aria-hidden=\"true\"><\/i><\/a>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-2cd30f60\" data-id=\"2cd30f60\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1cfae221 elementor-widget elementor-widget-ha-member happy-addon ha-member\" data-id=\"1cfae221\" data-element_type=\"widget\" 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href=\"https:\/\/www.google.com\/url?q=https:\/\/www.youtube.com\/playlist?list%3DPLbO5abv0daLUyYn4NaODAhv5adVUujtoB&#038;sa=D&#038;source=editors&#038;ust=1631648389710000&#038;usg=AOvVaw3cQ9g-25J1knmF-j_0Dgb3\"><span class=\"ha-btn-text\">Learn More<\/span> <i class=\"ha-btn-icon fas fa-chevron-right\" aria-hidden=\"true\"><\/i><\/a>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-51545c6e\" data-id=\"51545c6e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"featured_media":28563,"template":"elementor_header_footer","yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Aaron Ring, MD, PhD - Solve ME\/CFS Initiative<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/solvecfs.org\/research-and-registry\/ramsay-research-grants\/meet-the-researchers\/aaron-ring\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Aaron Ring, MD, PhD - Solve ME\/CFS Initiative\" \/>\n<meta property=\"og:description\" content=\"\u201cDiscovery of pathological autoantibodies in ME\/CFS and post-acute sequelae ofSARS-CoV-2 infection\u201dPrincipal Investigator:\u00a0Aaron Ring (MD, PhD)Yale University Home AARON RING \u201cDiscovery of pathological autoantibodies in ME\/CFS and post-acute sequelae ofSARS-CoV-2 infection\u201dPrincipal [&hellip;]\" \/>\n<meta property=\"og:url\" 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