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2019 is our biggest year yet! We have over 30 researchers working across seven projects. The group represents 12 academic centers and organizations. Three of the studies will be done collaboratively, integrating scientists from different labs.

Meet the teams below and click on the pictures to learn more about their research projects.

2019  


“Altered T cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Liisa Selin (PhD) and Anna Gil (PhD)
University of Massachusetts Medical School

 


“Possible class II MHC deficiency in patients with Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS)”

Bruno Paiva (PhD)
University of Navarra, Spain
Collaborators: Manuel Ruiz Pablos, Rosario Montero Mateo (MD), Aintzane Zabaleta Azpiroz (PhD), Diego Alignani (PhD), Idoya Rodriguez Serrano, Sonia Garate Luzuriaga


“Defining the postural contributors to post-exertional malaise (PEM) in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)”

Shad Roundy (PhD)
University of Utah
Collaborators: Cindy Bateman (MD), Turner Palombo, Andrea Campos


“Extensive characterization of the ME/CFS blood and CSF microbiome + virome ”

Nikos Kyripides (PhD), David Paez-Espino (PhD), Kris Fobes
DOE Joint Genome Institute and the Lawrence Berkeley National Laboratory; GeneSavvy
Collaborators: Amy Proal (PhD), Jonas Bergquist (MD, PhD), Robert Moir (PhD)


“Unraveling endothelial function in ME/CFS”

Francisco Westermeier (PhD)
FH JOANNEUM University of Applied Sciences, Austria
Collaborators: Nandu Gowami (MD, PhD), Nuno Sepulveda (PhD), Monika Riederer (PhD), Bernhard Wagner (PhD), Jennifer Blauensteiner (PhD)


“PARsing post-exertional malaise: does post-exertional autonomic recovery (PAR) impact post-exertional malaise?”

Kegan Moneghetti PhD, MBBS (hons), FRACP
Stanford University
Collaborators: Lily Chu (MD, MSHS), Jeffrey W. Christle (PhD, CEP), Donn Gavert (MS), Tullia Lieb


“Brain perfusion changes in chronic fatigue syndrome before and after exercise challenge”

Michael Van Elzakker (PhD) and Kenneth Kwong (PhD)
Massachusetts General Hospital, Harvard Medical School
Collaborator: Suk-tak (Phoebe) Chan (PhD)

 


Let the 2019 Ramsay Researchers know what their work means to you!

Use this form to send them a note with congrats and your hopes for their scientific studies that will unfold over the next year.


Learn more about Ramsay-supported studies from the 2016 – 2018 cycle below

Jump to 2017
Jump to 2016

 

2018 | The 2018 Request for Applications (RFA) received an enthusiastic response; double the number of applications were submitted compared to the 2017 cycle. From a collection of high quality proposals, seven projects received Ramsay funding at the beginning of 2019. Broadly, the investigators are researching mitochondrial dysfunction, immune-mediated inflammation, cell signaling, genetics, and infectious triggers. 

The Ramsay 2018 PI’s include two expert researchers leading their first original studies in ME/CFS and two highly innovative early-career stage researchers. This group of researchers has a particular emphasis on unbiased bioinformatics approaches and the use of methods novel to the ME/CFS field, such as evaluating exosomes (vesicles released from cells that play a role in intercellular communication) and producing reprogrammed neurons to examine neuro-metabolic and molecular changes. The studies are ongoing and results are anticipated soon.

>>> Click the researcher photos to learn more about each project.


“Characterization of Janus kinase (JAK) activation profiles in ME/CFS subgroups”

PI: Vincent Lombardi, PhD
University of Nevada, Reno
Collaborator: Kenny L. De Meirleir, MD, PhD


“Extracellular vesicles from ME/CFS Patients and their effect on human mast cells and microglia mediators secretion”

PI: Theoharis Theoharides, MD, PhD
Tufts University
Collaborator: Eirini Tsilioni, PhD


“Whole genome sequencing and analysis of ME/CFS”

PI: Elizabeth Worthey, PhD
HudsonAlpha Institute
Collaborator: Camille Birch, PhD


“Biomarkers of mitochondrial dysfunction and signaling in ME/CFS”

PI: Jonas Blomberg, MD, PhD
Anders Rosén, MD, PhD
Uppsala University and Linköping University, Sweden
Collaborators: Carl-Gerhard Gottfries, MD, PhD, and Olof Zachrisson, MD, PhD


“Endogenous retroviruses (ERVs) and their expression in chronic fatigue syndrome”

PI: Dawei Li, PhD
University of Vermont
Collaborators: Alain Moreau, PhD, Ron Davis, PhD, Wenzhong Xiao, PhD, and Alan Light, PhD


“ME/CFS In a Petri Dish” (an Investigation into ME/CFS using reprogrammed neurons)

PI: Malav Trivedi, PhD
Nova Southeastern University
Collaborator: Geeta Ravindran, PhD


“Cross-sectional study to assess the prevalence of APOE e4 alleles in patients with ME/CFS and the association with herpes virus infection”

PI: Hector Bonilla, MD
Stanford University
Collaborator: Joachim Hallmayer, MD

 


 

2017 |  The second year of the Ramsays supported five projects investigating the involvement of autoimmunity, infectious triggers, immune cell metabolism, and the gut microbiome in ME/CFS. The 2017 cycle funded a graduate student-level PI to lead a study on the gut virome in a cohort of people with ME/CFS and household controls. It also brought in an expert computational biologist new to the field to study a hypotheses of gut microbiota-immune system interaction using a bioinformatics approach. The group has produced two scientific publications in Frontiers in Immunology from a study initiated by Prof. Jonas Blomberg (Uppsala University, Sweden). More manuscripts from this group are in process.

>>> Click the researcher photos to learn more about each project.


Biomarkers for initiation (infection) and metabolic derangement in ME/CFS”

PI: Jonas Blomberg, MD, PhD
Jonas Bergquist, MD, PhD
Uppsala University
Collaborators: Carl-Gerhard Gottfries, MD, PhD, and Olof Zachrisson, MD, PhD


“Epigenetics in Immune Cells”

PI: Lubov Nathanson, PhD
Nova Southeastern University
Collaborators: Malav Trivedi, PhD, Vladimir Beljanski, PhD, and Elisa Oltra, PhD


“Gut Microbiome & Autoantigens”

PI: Eran Segal, PhD
Weizmann Institute of Science
Collaborator: Thomas Vogl, PhD


“Investigating alterations in the intestinal virome in CFS/ME”

PI: Fiona Newberry, PhD candidate
Quadram Institute and the University of East Anglia
Collaborators: Simon Carding, PhD, and Tom Wileman, PhD


“Metabolic Changes in T Cells & Monocytes”

PI: Carmen Scheibenbogen, MD
Charité—Universitätsmedizin Berlin in Germany
Collaborator: Franziska Sotzny, PhD

 


 

2016 |  The inaugural group of Ramsay researchers explored hypotheses in diverse areas of science, including: neuroinflammation, autoimmunity, immune cell metabolism, virology, and mitochondrial functioning. To-date, researchers have produced three publications in Frontiers in Immunology, Genomic Medicine (a Nature publication), and Brain Imaging & Behavior. Dr. Geraldine (Jo) Cambridge and Fane Mensah received extension funding from SMCI for their Ramsay project to investigate altered energy utilization in the B cells of ME/CFS patients in an expanded pool of samples. Notably, pilot data from Dr. Jarred Younger’s Ramsay project showing evidence of neuroinflammation in individuals with ME/CFS was used to obtain a large, multi-year grant from the National Institutes of Health.

>>> Click the researcher photos to learn more about each project.


“Evidence of widespread metabolite abnormalities in ME/CFS: assessment with whole-brain magnetic resonance spectroscopy”

PI: Jarred Younger, PhD
University of Alabama at Birmingham


“Metabolic Analysis Of B-cell Maturation In ME/CFS”

PI: Geraldine (Jo) Cambridge, PhD
University College London
Collaborators: Fane Mensah, PhD candidate, & Chris Armstrong, PhD


“HHV-6 Mediated Mitochondrial Modulation and Its Association to ME/CFS”

PI: Bhupesh Prusty, PhD
University of Wuerzberg


“Autoimmune Signature in ME/CFS”

PI: Carmen Scheibenbogen, MD
Charité—Universitätsmedizin Berlin in Germany
Collaborator: Franziska Sotzny, PhD