Meet The Researchers  |  About the Ramsay Award Program  |  Impact  |  Applying for an Award  |  Contact


The Ramsay Award Program is named after ME/CFS pioneer Dr. A. Melvin Ramsay, the recognized authority from 1955 until his death in 1990, whose sound descriptions of the disease have stood the test of time. The Ramsay Program has awarded grants to 16 projects over three application cycles from 2016 to 2018 – meet the research teams below and click the photos to learn more about each project.

Jump to 2017
Jump to 2018

 

2016 | The inaugural group of Ramsay researchers explored hypotheses in diverse areas of science, including: neuroinflammation, autoimmunity, immune cell metabolism, virology, and mitochondrial functioning. To-date, researchers have produced three publications in Frontiers in Immunology, Genomic Medicine (a Nature publication), and Brain Imaging & Behavior. More contributions to the scientific literature are anticipated from Ramsay 2016 projects. Dr. Geraldine (Jo) Cambridge and Fane Mensah received extension funding from SMCI for their Ramsay project to investigate altered energy utilization in the B cells of ME/CFS patients in an expanded pool of samples. Notably, pilot data from Dr. Jarred Younger’s Ramsay project showing evidence of neuroinflammation in individuals with ME/CFS was used in an application for R01 funding from the National Institutes of Health.

>>> Click the researcher photos to learn more about each project.


“Evidence of widespread metabolite abnormalities in ME/CFS: assessment with whole-brain magnetic resonance spectroscopy”

PI: Jarred Younger, PhD
University of Alabama at Birmingham


“Metabolic Analysis Of B-cell Maturation In ME/CFS”

PI: Geraldine (Jo) Cambridge, PhD
University College London
Collaborators: Fane Mensah, PhD candidate, & Chris Armstrong, PhD


“HHV-6 Mediated Mitochondrial Modulation and Its Association to ME/CFS”

PI: Bhupesh Prusty, PhD
University of Wuerzberg


“Autoimmune Signature in ME/CFS”

PI: Carmen Scheibenbogen, MD
Charité—Universitätsmedizin Berlin in Germany
Collaborator: Franziska Sotzny, PhD


 


 

2017 | The second Ramsay application cycle awarded funding to five projects investigating the involvement of autoimmunity, infectious triggers, immune cell metabolism, and the gut microbiome in ME/CFS. Prof. Jonas Blomberg published a hypothesis paper in Frontiers in Immunology as part of his research team’s Ramsay project. The studies are ongoing and results are anticipated soon.

>>> Click the researcher photos to learn more about each project.


Biomarkers for initiation (infection) and metabolic derangement in ME/CFS”

PI: Jonas Blomberg, MD, PhD
Jonas Bergquist, MD, PhD
Uppsala University
Collaborators: Carl-Gerhard Gottfries, MD, PhD, and Olof Zachrisson, MD, PhD


“Epigenetics in Immune Cells”

PI: Lubov Nathanson, PhD
Nova Southeastern University
Collaborators: Malav Trivedi, PhD, Vladimir Beljanski, PhD, and Elisa Oltra, PhD


“Gut Microbiome & Autoantigens”

PI: Eran Segal, PhD
Weizmann Institute of Science
Collaborator: Thomas Vogl, PhD


“Investigating alterations in the intestinal virome in CFS/ME”

PI: Fiona Newberry, PhD candidate
Quadram Institute and the University of East Anglia
Collaborators: Simon Carding, PhD, and Tom Wileman, PhD


“Metabolic Changes in T Cells & Monocytes”

PI: Carmen Scheibenbogen, MD
Charité—Universitätsmedizin Berlin in Germany
Collaborator: Franziska Sotzny, PhD

 


 

2018 | The 2018 Request for Applications (RFA) received an enthusiastic response; double the number of applications were submitted compared to the 2017 cycle. From a collection of high quality proposals, seven projects received Ramsay funding at the beginning of 2019. Broadly, the investigators are researching mitochondrial dysfunction, immune-mediated inflammation, cell signaling, genetics, and infectious triggers.

>>> Click the researcher photos to learn more about each project.


“Characterization of Janus kinase (JAK) activation profiles in ME/CFS subgroups”

PI: Vincent Lombardi, PhD
University of Nevada, Reno
Collaborator: Kenny L. De Meirleir, MD, PhD


“Extracellular vesicles from ME/CFS Patients and their effect on human mast cells and microglia mediators secretion”

PI: Theoharis Theoharides, MD, PhD
Tufts University
Collaborator: Eirini Tsilioni, PhD


“Whole genome sequencing and analysis of ME/CFS”

PI: Elizabeth Worthey, PhD
HudsonAlpha Institute
Collaborator: Camille Birch, PhD


“Biomarkers of mitochondrial dysfunction and signaling in ME/CFS”

PI: Jonas Blomberg, MD, PhD
Anders Rosén, MD, PhD
Uppsala University and Linköping University, Sweden
Collaborators: Carl-Gerhard Gottfries, MD, PhD, and Olof Zachrisson, MD, PhD


“Endogenous retroviruses (ERVs) and their expression in chronic fatigue syndrome”

PI: Dawei Li, PhD
University of Vermont
Collaborators: Alain Moreau, PhD, Ron Davis, PhD, Wenzhong Xiao, PhD, and Alan Light, PhD


“ME/CFS In a Petri Dish” (an Investigation into ME/CFS using reprogrammed neurons)

PI: Malav Trivedi, PhD
Nova Southeastern University
Collaborator: Geeta Ravindran, PhD


“Cross-sectional study to assess the prevalence of APOE e4 alleles in patients with ME/CFS and the association with herpes virus infection”

PI: Hector Bonilla, MD
Stanford University
Collaborator: Joachim Hallmayer, MD