Research Library Portal

ME/CFS is one of the top unsolved medical mysteries science has to tackle today; the field of ME/CFS research is ripe for discovery. There are nearly 5,000 articles in the peer-reviewed literature related to ME/CFS.  Our full research library houses more than 130 posts, all readily searchable and accessible. Simply type the topic you are looking for into the search field in the top right of your screen.

Here are some of our most accessed, based on the most common ME/CFS symptoms:

Post-Exertional Malaise (PEM) – A cardinal symptom of ME/CFS, PEM occurs following mental or physical exertion and is described as a worsening of symptoms lasting 24 hours or more.

Unrefreshing Sleep – Disrupted and unrefreshing sleep causes ME/CFS patients to wake up feeling tired even after periods of rest, to experience excessive daytime sleepiness and to have difficulty falling asleep and staying asleep.

Concentration Problems – Considered by many to be the most serious and debilitating symptom, patients experience difficulties with attention, concentration and memory. This has been linked to problems in how the brain processes information – particularly information processing speed and complex information processing.

Pain – For some time, pain was not thought to be a prominent symptom of ME/CFS, but muscle, joint and headache pain are all common in ME/CFS patients.

It is likely that the four major symptoms of ME/CFS – post-exertional malaise, unrefreshing sleep, concentration problems, and pain – are intertwined, each affecting the other and potentially exacerbating the condition.

To access the published papers available on PubMed:



More information on current research, government activity, grants & funding opportunities: