RAMSAY 2018: MEET PROFESSOR JONAS BLOMBERG, MD, PHD & DR. ANDERS ROSÉN, MD, PHDOctober 9, 2018
“Biomarkers of mitochondrial dysfunction and signaling in ME/CFS”
A project summary as written by Profs. Blomberg and Rosen:
Our working hypothesis of ME/CFS pathogenesis is that a person predisposed for ME is provoked to react with the major energy metabolic organelle, the mitochondria. We want to explore why after an infection, a major energy metabolic change takes place, creating a severe restriction in daily life and causing a profound lack of energy, affecting both muscular and mental (cognitive) functions. We will investigate the presence of antibodies in ME to mitochondrial proteins, especially the pyruvate dehydrogenase complex. We will also utilize our recently published reports of an innate immune mechanism which releases mtDNA into extracellular space when stimulated by certain DNA structures, and a hypothetical explanation for pathogenesis of ME.
We are fortunate to collaborate with the most experienced ME/CFS clinic in Sweden, the Gottfries clinic, in Mölndal. Prof. Carl-Gerhard Gottfries and Dr. Olov Zachrisson provided us with a collection of 198 blood samples from anonymous ME/CFS patients and controls. Their extensive clinical experience of ME/CFS is a guarantee for the clinical relevance of our research. Appropriate ethical permissions are at hand. The ME/CFS patients were diagnosed using the stringent Canadian criteria.
The laboratories of Anders Rosén in Linköping and Jonas Blomberg in Uppsala are uniquely suited for a collaborative effort to better understand involvement of mitochondria in the immunopathogenesis of ME/CFS, and to develop biomarkers for the disease.