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X-WR-CALDESC:Events for Solve ME/CFS Initiative
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DTSTART;TZID=America/Los_Angeles:20260428T150000
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DTSTAMP:20260716T054515
CREATED:20260225T175319Z
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UID:43389-1777388400-1777392000@solvecfs.org
SUMMARY:The Discovery of Target Antigens for Dysfunctional T Cells in ME/CFS and Long COVID
DESCRIPTION:Dr. Liisa Selin\, Dr. Ayano Kohlgruber\, and Dr. Roshan Kumar received a Solve ME/CFS Catalyst Award for their study searching for the exact proteins recognized by T-cell receptors from a person with ME/CFS and a person with Long Covid. \nThese disease-associated T cells include “exhausted” CD8+ T cells and “double-positive” CD4+/CD8+ T cells (which are found in people with autoimmune diseases\, too). The researchers hypothesize that these T cells recognize fragments of microbial proteins critical for developing the disease. The microbial protein fragments may overstimulate and exhaust the T cells. \nAlso\, fragments of human proteins may resemble these microbial protein fragments; thus\, the disease-associated T cells may cross-react with human proteins to drive an autoimmune response. \nIn this study\, the research team will screen a library of protein fragments from microbes (viruses and bacteria) that are associated with developing Long Covid or ME/CFS (e.g.\, SARS-CoV-2\, B. burgdorferi\, enteroviruses)\, and a library of protein fragments from humans (to find self-antigens). \nIf successful\, these deliverables would be important for understanding how much persisting pathogens or self-antigens can exhaust the immune system\, and how dysfunctional and exhausted immune responses contribute to ME/CFS and Long Covid. \nIn this webinar hosted by Solve M.E. VP of Scientific Programs Dr. Jessica Maya\, the panelists will discuss the study and how this work could also produce new disease biomarkers and suggest new treatments for patient subgroups\, as well as how the libraries of human leukocyte antigen–displayed microbial and human protein fragments established by this work could be valuable resources for future ME/CFS and Long Covid studies.
URL:https://solvecfs.org/event/the-discovery-of-target-antigens-for-dysfunctional-t-cells-in-me-cfs-and-long-covid/
CATEGORIES:Research,Webinar
ATTACH;FMTTYPE=image/png:https://solvecfs.org/wp-content/uploads/2026/02/SelinSolveWebinarApril282026JMFinal-1.png
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