GUT TISSUE BIOPSY SAMPLES STUDIED

Researchers in Belgium, Russia, Hungary and the U.S. (Whittemore Peterson Institute) reported results of a preliminary analysis of de-identified gut tissue obtained from 12 patients meeting Canadian and Fukuda definitions for ME/CFS and CFS and eight control subjects. Tissue samples were obtained during clinical diagnostic procedures and limited information was available about the subjects. Eight of 12 […]

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ALTERED B CELL SUBSETS:

ME/CFS with 33 matched healthy controls. They did a detailed analysis of B cell subsets and founded changes that suggest “a subtle tendency to autoimmunity.” “The CFS cohort had significantly greater proportions of transitional B cells, naive B cells and reduced proportions of plasmablasts expressed as a percentage of B cells. B cells produce antibodies and […]

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T & NK CELL SUBSET DIFFERENCES:

Researchers in Spain studied fresh blood samples collected from 22 CFS patients (94-Fukuda criteria) who did not have concurrent evidence of infections and compared function of several immune cell subsets to 30 healthy controls. They found differences in T cells and natural killer (NK) cell subsets, but not B cells. (Journal of Translational Medicine, Mar. […]

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GULF WAR BRAIN BIOMARKER

Dr. James Baraniuk and Georgetown Univ. colleagues studied 31 chronically ill Gulf War veterans and 20 sedentary, healthy controls using functional MRI testing. Gulf War Illness subjects had significantly correlated fatigue, pain, hyperalgesia and increased axial diffusivity in the right inferior fronto-occipital fasciculus area of the brain, a potential biomarker for Gulf War illness that […]

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CFS & ME Compared

Using 3 independent data sets (including the SolveCFS BioBank), Dr. Leonard Jason and colleagues found that fewer subjects met criteria for ME than CFS and symptoms were more severe and impairments were greater for subjects who met ME criteria. (Fatigue: Biomedicine, Health & Behavior, Mar. 20, 2013)

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HEART RATE VARIABILITY DURING SLEEP

This study by Drs. Benjamin Natelson and Fumharu Togo looked for a relationship between heart rate variability (HRV) and subjective sleep quality. The 52 female patients with CFS showed evidence for sleep disruption in the form of significantly reduced total sleep time, reduced sleep efficiency, and changes in whole night HRV when compared to matched […]

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ABNORMAL PAIN PROCESSING

19 patients with CFS/FM, 16 patients with rheumatoid arthritis (RA) and 18 sedentary controls participated in a double-blind crossover trial of a single dose (1 g) of acetaminophen with tests of pressure pain threshold before and after treatment. The group of Belgian researchers led by Dr. Mira Meeus report, “CFS/FM patients present more central pain […]

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Spinal Fluid Proteins

Researchers at six institutions led by the University of Medicine and Dentistry of New Jersey and Pacific Northwest National Laboratory reported finding 738 unique protein markers in spinal fluid samples collected from 43 CFS patients and compared to samples from 25 neurologic post-treatment Lyme disease patients and 11 healthy control subjects. They were able to distinguish […]

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FM AS A SPECTRUM DISORDER

Researchers in Kansas and Germany report results of a large population survey of 2,445 people selected randomly from the German population. 2.1% of the population met 2010 criteria for FM. Prevalence was similar in women and men, a difference from past studies that showed more women than men had FM. They found a spectrum of […]

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LOW-DOSE NALTREXONE SHOWS PROMISE

Researchers at Stanford University report that a study of 31 women with fibromy algia (FM) shows promising results for low-dose naltrexone to reduce pain and improve mood and satisfaction with life. The study used a cross-over design and participants received medication for 12 weeks and placebo for four weeks with a four-week follow-up period. Abstract from […]

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