Ramsay Research Team 1 – Exploring Brain Inflammation by Measuring Temperature

The study from Dr. Jarred Younger of the University of Alabama at Birmingham is entitled “Advanced Non-Invasive Analysis in ME/CFS Diagnosis and Treatment Decisions.” This study will use a magnetic resonance spectroscopic thermometry (MRSt) technique to assess absolute temperature across the entire brain. This technique allows researchers to investigate the pathophysiology (in other words, the […]

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The Ramsay Award Program Peer-Review Process

SMCI is the only ME/CFS organization to award seed grants for preliminary research, historically giving out seed grants once every three years. Our new, annual seed grant program, The Ramsay Award Program, will now give awards to promising researchers annually. When the Ramsay Award Program was established, we recognized that the development of a transparent, […]

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December Research 1st – Dr. Nahle’s Letter

Dear Friends, The results of the 2016 Ramsay Award Program are in! The Ramsay Award Program is a newly announced, annual research grants competition in basic, preclinical, clinical, and epidemiological research open to investigators at any career stage who are interested in studying ME/CFS. As described before, the program’s three main objectives are to 1) […]

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The Bioenergetic Health Index of NK Cells as a Diagnostic Tool for Chronic Fatigue Syndrome

A project summary as written by Isabel Barao-Silvestre, Ruben Dagda, and Victor Darley-Usmar: Natural Killer (NK) lymphocytes are a critical first defense against viruses and cancer. NK cell dysfunction is a pathological hallmark in chronic fatigue syndrome (CFS). CFS patients have difficulties controlling EBV, HHV6, HCMV, HSV-1 and -2 chronic viral infections and many develop […]

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Autoimmune Signature in CFS/ME

A project summary as written by Carmen Scheibenbogen and Madlen Lobel: There is ample evidence of an autoimmune pathomechanism in a subset of patients with CFS. We could recently show autoantibodies against adrenergic (AdR) and muscarinic acetylcholine (MAchR) receptors in a subset of CFS/ME patients which might be associated with disease pathology (1). Norwegian studies […]

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Metabolic Analysis of B-Cell Maturation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

A project summary as written by Geraldine Cambridge, Fane Mensah, and Chris Armstrong: Many viral and other infectious agents have been reported to cause or trigger the symptoms described by patients with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The variety of pathogens associated with ME/CFS however suggests that a single agent is not responsible and that […]

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Advanced Non-Invasive Analysis in ME/CFS Diagnosis and Treatment Decisions

A project summary as written by Jarred Younger: In this project, we will test a magnetic resonance spectroscopic thermometry (MRSt) technique to assess absolute temperature across the entire brain. We will use the technique to investigate the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a condition of unknown etiology that is characterized by profound fatigue […]

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HHV-6 Mediated Mitochondrial Modulation and Its Association to ME/CFS

A project summary as written by Bhupesh Prusty: Infections are frequently associated with chronic disease development and likely, play crucial roles in the onset or progression of several human disorders that are not classified as infectious diseases. Myalgic encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) is one such example. However, the precise role of pathogens in ME/CFS […]

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Solve ME/CFS Initiative Joins Letter on CBT and GET

A letter jointly signed by the Solve ME/CFS Initiative (SMCI) and over 50 other ME/CFS organizations and advocates was sent to the Centers for Disease Control and Prevention (CDC) this week. The letter, authored by leading advocate and SMCI board member Mary Dimmock, calls for action on the cognitive behavioral therapy (CBT) and graded exercise […]

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