Ramsay Research Team 5 – The Potential Role of HHV-6 in ME/CFS

This study from Dr. Bhupesh Prusty (Julius Maximilian University of Wurzburg) is entitled “HHV-6 Mediated Mitochondrial Modulation and Its Association to ME/CFS.” While the precise role of pathogens in the development of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remains mostly uncharacterized, human herpesvirus 6 (HHV-6) is frequently associated with the disease (as well as several other […]

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Ramsay Research Team 4 – Identifying Autoimmune Signatures in ME/CFS

This study from Dr. Carmen Scheibenbogen (Charite University Medicine Berlin) and Madlen Lobel (Charite Universitatsmedizin Berlin) is entitled “Autoimmune Signature in CFS/ME.” It combines in-depth genetic screening methodologies with the study of autoimmune factors regulating a specific type of surface receptors important in cellular signaling and function. Three specific cellular and genetic autoimmune traits in […]

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Ramsay Research Team 3 – Metabolic Assessment of Natural Killer Cells in ME/CFS Using the Bioenergetics Health Index

This study, from Drs. Isabel Barao-Silvestre (University of Nevada Reno), Ruben Dagda (University of Nevada Reno), and Victor Darley-Usmar (University of Alabama at Birmingham), is entitled “The Bioenergetic Health Index of NK Cells as a Diagnostic Tool for Chronic Fatigue Syndrome.” Natural killer (NK) lymphocytes (a type of white blood cell) are a critical first […]

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Ramsay Research Team 2 – Studying B-Cell Function, Maturation, and Biochemical Alteration with Rituximab-Based Therapy

This study, from Dr. Geraldine Cambridge (University College London), Fane Mensah (University College London), and Chris Armstrong (University of Melbourne), is entitled “Metabolic Analysis of B-Cell Maturation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.” The study theorizes that while “many viral and other infectious agents have been reported to cause or trigger the symptoms described by patients […]

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Ramsay Research Team 1 – Exploring Brain Inflammation by Measuring Temperature

The study from Dr. Jarred Younger of the University of Alabama at Birmingham is entitled “Advanced Non-Invasive Analysis in ME/CFS Diagnosis and Treatment Decisions.” This study will use a magnetic resonance spectroscopic thermometry (MRSt) technique to assess absolute temperature across the entire brain. This technique allows researchers to investigate the pathophysiology (in other words, the […]

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The Ramsay Award Program Peer-Review Process

SMCI is the only ME/CFS organization to award seed grants for preliminary research, historically giving out seed grants once every three years. Our new, annual seed grant program, The Ramsay Award Program, will now give awards to promising researchers annually. When the Ramsay Award Program was established, we recognized that the development of a transparent, […]

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December Research 1st – Dr. Nahle’s Letter

Dear Friends, The results of the 2016 Ramsay Award Program are in! The Ramsay Award Program is a newly announced, annual research grants competition in basic, preclinical, clinical, and epidemiological research open to investigators at any career stage who are interested in studying ME/CFS. As described before, the program’s three main objectives are to 1) […]

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The Bioenergetic Health Index of NK Cells as a Diagnostic Tool for Chronic Fatigue Syndrome

A project summary as written by Isabel Barao-Silvestre, Ruben Dagda, and Victor Darley-Usmar: Natural Killer (NK) lymphocytes are a critical first defense against viruses and cancer. NK cell dysfunction is a pathological hallmark in chronic fatigue syndrome (CFS). CFS patients have difficulties controlling EBV, HHV6, HCMV, HSV-1 and -2 chronic viral infections and many develop […]

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Autoimmune Signature in CFS/ME

A project summary as written by Carmen Scheibenbogen and Madlen Lobel: There is ample evidence of an autoimmune pathomechanism in a subset of patients with CFS. We could recently show autoantibodies against adrenergic (AdR) and muscarinic acetylcholine (MAchR) receptors in a subset of CFS/ME patients which might be associated with disease pathology (1). Norwegian studies […]

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Metabolic Analysis of B-Cell Maturation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

A project summary as written by Geraldine Cambridge, Fane Mensah, and Chris Armstrong: Many viral and other infectious agents have been reported to cause or trigger the symptoms described by patients with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The variety of pathogens associated with ME/CFS however suggests that a single agent is not responsible and that […]

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