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JANUARY 2017

RESEARCH 1ST NEWS | JANUARY 2017


Dear Friends,

With every new year, we renew our commitment to remain the uncompromising force working on behalf of patients. Indeed, our dedication to finding solutions to this disease has never been stronger or better focused. And while we scrape a dollar from here and a penny from there to survive as a non-profit research organization, we are unashamedly proud to see our investments in research doubling if not tripling across the disease spectrum as a result of this frugality.  

Last January, we committed to the following:
 
Creating environments in which real and durable research and advocacy collaborations develop and flourish, reframing a narrative through which all voices in ME/CFS can be heard and respected. Through unity and cross-pollination, we felt we could effectively… Read More

Yours,

Zaher Nahle
Chief Scientific Officer
Vice President for Research 
Solve ME/CFS Initiative

research roundup

New Study Explores Role of Energy-Regulating Enzyme PDH in ME/CFS

A new study entitled “Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome” by Fluge et al. was recently published in the leading Journal of Clinical Investigation.

The study examined a total of 300 participants (approximately 200 ME/CFS patients, diagnosed according to the Canadian Consensus Criteria, alongside 100 healthy controls). Using blood samples, analysis of participants’ metabolism was performed, leading to the identification of specific biochemical changes in ME/CFS patients versus their controls.

Specifically, blood samples showed that levels...

TO READ MORE, GO HERE.

Dr. Maureen Hanson Visits SMCI to Discuss Ongoing Collaboration

On January 5, Dr. Maureen Hanson of Cornell University visited SMCI’s Los Angeles headquarters. Dr. Hanson’s visit provided the opportunity to meet with SMCI President Carol Head and Chief Scientific Officer and Vice President for Research Dr. Zaher Nahle to discuss ongoing projects and collaboration on a number of studies. 

As you may know, Dr. Hanson, together with Dr. Sue Levine of The Levine Clinic in New York and metabolomics leader Metabolon, is a partner in one of our four SMCI-Directed Research Studies. The initial testing phase of this pathway and biomarker discovery study has been completed.

TO READ MORE, GO HERE.

other news

Non-Invasive Diagnostic Test Project Seeks to Detect ME/CFS

This week, we highlight the Cathleen J. Gleeson PhD Fund and our collaborative partnership with the University of Washington on diagnostic testing in ME/CFS. 

This study of diagnostics and metabolic imaging uses advanced, non-invasive magnetic resonance spectroscopy (MRS) to measure muscle metabolites in ME/CFS patients before and after fatiguing exercise. 

Pilot testing conducted earlier through this project compared a single patient with ME/CFS to that of a matched healthy control. Preliminary analysis revealed abnormal...

TO READ MORE, GO HERE.

New SMCI-Directed Research Study Explores Immuno-senescence 

Another of our SMCI-Directed Research Studies is being conducted in partnership with Dr. Sheila Stewart of Washington University in St. Louis in collaboration with Dr. Masashi Narita of the Narita Group at Cambridge University in England. This study explores immuno-senescence and cell-cycle analysis in the pathophysiology (or functional changes that accompany a particular syndrome or disease) of ME/CFS. 

As described by Dr. Stewart, recent work has shown patients with ME/CFS to have alterations in immune cells as well as in the p38 Map Kinase (p38MPAK), a key pathway...

TO READ MORE, GO HERE.

NIH Funding Opportunity Announcements Rescheduled for January Release

The ME/CFS community has been waiting many, many years for new, ME/CFS-specific funding to be made available at the National Institutes of Health (NIH). In September 2016, the NIH announced that new funds would be available that December in the form of two Funding Opportunity Announcements (FOAs)—both of which would create new ME/CFS research consortia (or collaborative groups).

In late December, the NIH released an update on the forthcoming FOAs, which are now expected by the end of this month. The NIH has said the delay is due to multiple institutes contributing to the documents, which slows down the process. However, they note that the January release date has no effect on the research timeline itself.

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