Research 1st News  |  September 2014   
Research 1st News is your free and informative monthly e-newsletter from the Solve ME/CFS Initiative (formerly the CFIDS Association of America). Please forward it to someone you know that may benefit from it.
As the seasons change, we remain steadfast in our effort to make ME/CFS widely understood, diagnosable, and treatable. We are squarely focused on patient-centered research aimed at identifying safe and effective therapies to eradicate this dreadful and debilitating disease. 

In this issue we share some more results coming out of our funded studies in the research digest; link to our webinar series, recordings and registration; feature a 3-part series on the importance of a physical exam in ME/CFS; bring you an update on the P2P Workshop for ME/CFS; and highlight an inspiring patient story.

Bringing this kind of valuable information to you is made possible through the generous donations of patients and their loved ones who fund our work. We are especially grateful for all who offer any level of financial support. Together we can Solve ME/CFS.

Carol E Head
President and CEO
Research Digest - September: Cortisol in ME/CFS

Cortisol is a hormone that is produced in the adrenal glands where it enters into the circulation to dampen inflammation. It does this by entering into the cytoplasm of cells, binding to the cortisol receptor (called the glucocorticoid receptor) and then moving into the cell nucleus to bind to DNA and regulate the expression of inflammatory molecules.

Cortisol is an essential hormone for immune function and many studies have shown that cortisol is low in ME/CFS patients – known as hypocortisolism. Recent articles find increased cortisol receptor expression is associated with post-exertion malaise (PEM), low cortisol is associated with more severe PEM and a return of cortisol to normal levels is associated with recovery.

In this month’s research digest, we review three studies that look at the effect of cortisol on function and post-exertional malaise in ME/CFS.

2014 Webinar Series!

The Solve ME/CFS Initiative (SMCI) is bringing you a free, monthly webinar. Don't miss this chance to get cutting edge research updates directly from our funded investigators!

Research Institute Without Walls – Progress & Promise
Held on July 31

Patrick McGowan PhD: Epigenetics of ME/CFS
Held on Aug 21

Dane Cook PhD: Deciphering Post-Exertional Malaise
Held Sept 18

Additional webinars for November & December will be announced soon!

You must RSVP to participate live - all are welcome.

Recordings of all webinars will be posted to our YouTube channel within a week of the live date, for ready access to the information.

Guest Blog: Dr Peter Rowe - Physical Exam in ME/CFS
As medicine becomes more and more dependent on sophisticated technology, the physical exam is in danger of becoming a lost art. In this 3-part blog series, Dr. Peter Rowe of Johns Hopkins University discusses “Is the physical exam in CFS normal?” 

We are certain that this information will be of great value to both you and your doctor and will clearly illustrate the value of a comprehensive physical examination of ME/CFS.


P2P Workshop Registration OPEN
Registration is now open for the Pathways to Prevention workshop for Advancing the Research on ME/CFS. 
Interested individuals may register to attend live or participate via webcast. 

It is our hope that many stakeholders will participate in this process in order to ensure the patients have a strong presence and a voice.

Guest Blog: Hope Springs Eternal
In this month's guest blog, Laurie shares her journey with the setbacks and struggles of ME/CFS... and her story of hope.

Did you know that the Solve ME/CFS Initiative is funded entirely by individuals who choose to make a difference for patients afflicted with this debilitating illness? We count on people like you to support the progress of our Research Institute Without Walls and our SolveCFS Biobank. In fact, we can’t do it without you.

No gift is too big or too small. You can make a difference now by visiting and making a contribution to our Annual Campaign.

Your support brings hope to patients who are suffering, and makes a real difference in solving ME/CFS. Thank you!