Loss of Stress Response in Viral Infection

A perspective article reviews evidence for and proposes the long-term consequences to human hosts when the heat-shock protein response is impaired following viral infections. CFS is one of the conditions they explore, suggesting that “CFS is not the result of a specific infection but rather a more general response of the body to infection.” They cite research showing that heat shock protein levels “fail to rise with exercise in subjects with infection-associated CFS, and in fact decreased from baseline — which may explain why CFS subjects often complain of exhaustion after moderate exercise (citing Jammes et al, 2011). Furthermore, CFS muscle biopsies contain mitochondria with [defects] consistent with an impaired intracellular stress defense (citing Myhill et al, 2009).” (Cell Stress and Chaperones, July 14, 2012)

Tags: , July 14, 2012