Kindling Model for Etiology

Dr. Leonard Jason’s group at DePaul University built on earlier publications that propose kindling as a model for ME/CFS. Kindling occurs when an organism is exposed repeatedly to an initially sub-threshold stimulus resulting in hypersensitivity and spontaneous seizure-like activity. The authors proposed that seizure activity spreads to nearby areas in the brain, leading to the varied symptoms that occur among patients with ME/CFS. Kindling may also be responsible for high levels of oxidative stress, which has been found in patients with ME/CFS. (Neuroscience & Medicine, March 2011; open access.)

Tags: , , March 13, 2011