Inflammatory Cytokine and Chemokine Signature

Blood samples collected from 118 CFS patients who had tested positive for XMRV were cytokinescompared to samples obtained from 138 controls subjects. Concentrations of 26 plasma markers belonging to different immune classes were evaluated by xMAP technology from Luminex. Of the 26 cytokines and chemokines tested, 19 were different between patients and controls. The greatest difference was between interleukin-8, a major mediator of the inflammatory response, which was upregulated in cases compared to controls. The authors from the Whittemore Peterson Institute and University of Reno suggest that this data supports the description of XMRV-related CFS as an inflammatory disease and propose that multiplex cytokine and chemokine analysis in conjunction with XMRV testing “may serve as a useful diagnostic for CFS.” (IN VIVO, May 16, 2011)

Tags: , , May 16, 2011