Research Update

Deciphering Post-Exertional Malaise

November 21, 2014

On September 18, 2014, Dane B. Cook, Ph.D., Associate Professor of Kinesiology at the University of Wisconsin, Madison and a Solve ME/CFS Initiative 2011 funded investigator, presented our most popular webinar of the year on the system biology approach his team is taking to provide a clear picture as to what causes post-exertional malaise. In this guest post for our blog, Dr. Cook reviews the material presented and tackles the many questions we received from webinar participants.

The Importance of a Representative Patient Population for Research

November 18, 2014

Being able to offer researchers access to ME/CFS patients with demographic and clinical characteristics that represent the full range of people affected with ME/CFS removes a significant hurdle all researchers face. With the SolveCFS BioBank™ we can make ME/CFS research more appealing and accessible. But how do we ensure our SolveCFS BioBank™ is representative of the entire patient population? READ MORE….

SMCI Survey Data Analyzed for Publication

November 7, 2014

Leonard A. Jason, along with Laura Nicholson, Diana Ohanian, Kelly O’Connor, & Abigail Brown, all of DePaul University are preparing a paper titled, “ME/CFS Patient Perspectives on Name Change & Priorities for Healthcare Provider Education.” This paper is based on the results of an SMCI survey facilitated prior to an IOM committee meeting earlier this year. Read the summary now, in advance of publication…

Research Digest – October 2014: The Search for Diagnostic Certainty

October 24, 2014

Currently ME/CFS is defined by symptoms that are common in many other medical and psychiatric diseases. A lack of specific biomarkers and clear diagnostic criteria often leads to misdiagnosis and muddied research results. In this month’s Research Digest we review three different studies that seek to identify more specific biomarkers for ME/CFS. READ MORE…

P2P Draft Evidence Review

October 20, 2014

The Pathway to Prevention draft evidence review has been released. Can a process that seems inappropriate for ME/CFS help inform a path forward? SMCI has utilized the collective brainpower of our Research Advisory Council, led by our scientific director, Suzanne D Vernon, PhD, to perform a careful review and response to the Evidence-Based Practice Centers’ draft evidence-based review for ME/CFS. READ MORE…

Research Digest – September 2014: Cortisol in ME/CFS

September 15, 2014

Cortisol is an essential hormone for immune function and many studies have shown that cortisol is low in ME/CFS patients – known as hypocortisolism. In this month’s research digest, we review three studies that look at the effect of cortisol on function and post-exertional malaise in ME/CFS…

Research Digest – August 2014: More Results from the SolveCFS BioBank

August 22, 2014

More results from the work being done through the SolveCFS BioBank: We are pleased to report the publication of the initial BioBank study on XMRV and the publication of the first study of epigenetics in ME/CFS. Both used the clinical information and samples from the SolveCFS BioBank that were collected in 2010. READ MORE…

Guest Blog: Roger Dodd, PhD – Retrovirus Testing in Retrospect

August 21, 2014

In response to some lingering questions we recently received from patients concerning a positive test result for XMRV, Roger Dodd, PhD, Vice President of Biomedical Services Research and Development at the American Red Cross, provides this guest post on retrovirus testing and why ME/CFS patients need not be concerned with a positive XMRV test result…

Breaking News: Chemical Changes in Immune Cell DNA from ME/CFS Patients

August 12, 2014

Breaking News: Research conducted in partnership with and funded by the Solve ME/CFS Initiative (SMCI) was published today in the high impact and open access journal PLOS ONE. We are pleased to announce the first study to report epigenetic modifications throughout the genome in female ME/CFS patients compared to a matched sample of healthy controls. READ MORE…

Guest Blog: Mark A. Demitrack, MD, FAPA – Neurobiology of ME/CFS

July 17, 2014

Far too often, ME/CFS patients are met with healthcare providers who do not believe in the biological nature of the disease. In this guest blog post, Mark Demitrack, MD, FAPA describes how for a long time he has advocated for and used an integrated approach to understand how the brain is involved in the biology of ME/CFS. READ MORE…